发明名称 |
Nucleic acid vaccines for prevention of flavivirus infection |
摘要 |
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.
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申请公布号 |
US7227011(B2) |
申请公布日期 |
2007.06.05 |
申请号 |
US20010826115 |
申请日期 |
2001.04.04 |
申请人 |
UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION |
发明人 |
CHANG GWONG-JEN J. |
分类号 |
C07H21/04;C12N15/09;A61K31/711;A61K39/00;A61K39/12;A61K48/00;A61P31/14;C07K14/18;C07K16/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/40;C12Q1/70;G01N33/53;G01N33/569 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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