| 摘要 |
< <IMG> PCT WORLD INTELLECTUAL PROPERTY ORGANIZATION International Bureau INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT ) (51) International Patent Classification 5: (11) International Publication Number: WO 91/16454 C12Q 1/68, C07H 21/00 Al C12P 19/34 (43) International Publication Date: 31 October 1991 (31.10.91) (21) International Application Number: PCT/EP91/00743 (74) Agents: GUTMANN, Ernest et al.; Ernest Gutmann - Yves Plasseraud S.A., 67, boulevard Haussmann, F- (22) International Filing Date: 18 April 1991 (18.04.91) 75008 Paris (FR). (30) Priority data: (81) Designated States: AT (European patent), AU, BE (Eu ro- 90401054.3 18 April 1990 (18.04.90) EP pean patent), CA, CH (European patent ), DE (Euro- (34) Countries for which the regional pean patent), DK (European patent), ES (European pa- or international application tent), FR (European patent), GB (European patent), GR was filed: GB et al. (European patent), HU, IT (European patent), JP, LU (European patent), NL (European patent), SE (Euro- pean patent), US. (71) Applicant (for all designated States except US): N.V. IN- NOGENETICS S.A. [BE/BE]; Industriepark Zwijna- arde 7, Box 4, B-9710 Ghent (BE). Published With international search report. (72) Inventors; and Before the expiration of the time limit for amending the (75) Inventors/Applicants (for US only) : ROSSAU, Rudi [BE/ claims and to be republished in the event of the receipt of BE]; Wilgehoevestraat 45, B-2070 Ekeren (BE). VAN amendments. HEUVERSWYN, Hugo [BE/BE]; Colmanstraat 62, B- 9288 Laarne (BE). (54)Title: HYBRIDIZATION PROBES DERIVED FROM THE SPACER REGION BETWEEN THE 1 6S AND 23S rRNA GENES FOR THE DETECTION OF NON-VIRAL MICROORGANISMS (57) The invention relates to a probe consisting of at least about 15 nucleotides from the spacer region between rRNA genes of a non-viral organism, particularly prokaryotic organism and more particularl y bacteria, and preferably from about 15 nucleotides to about the maximum number of nucleotides of the spacer region and more preferably from about 15 to about 100 nucleotides to be used for the detection of non-viral microorganisms.
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