PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

摘要

The invention concerns 1-substituted piperazinylacylpiperidine derivatives of general formula (I), wherein: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom, a trifluoromethyl radical, C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an -OR5 group, a -CH2OR5 group, a -NR6R7 group; a -NR8COR9 group; a -NR8CONR10R11 group; a -CH2NR12R13 group; a -CH2NR8CONR14R15 group; a C1-C4 alkoxycarbonyl; a -CONR16R17 group; or R3 forms a double bond between the carbon atom whereto it is bound and the neighbouring carbon atom of the piperidine cycle; R4 represents an aromatic group selected among (II), said aromatic groups being unsubstituted, monosubstituted or disubstituted by a substituent selected independently among a halogen atom, a C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethyl radical. The invention also concerns a method for preparing said compounds and their therapeutic use.