| 发明名称 |
METHODS FOR THE PREPARATION, ISOLATION AND PURIFICATION OF EPOTHILONE B, AND X-RAY CRYSTAL STRUCTURES OF EPOTHILONE B |
| 摘要 |
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
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| 申请公布号 |
RS20050235(A) |
申请公布日期 |
2007.06.04 |
| 申请号 |
YUP20050235 |
申请日期 |
2003.09.22 |
| 申请人 |
BRISTOL MYERS SQUIBB COMPANY |
发明人 |
BENIGNI DANIEL;STANKAVAGE ROBERT;CHIANG SHU-JEN;HOU HSING;EAGAN BRUCE;GU DENNIS;HOU DAVID;MINTZMYER LES;TULLY THOMAS;DAVIS BRIAN;HARGO IVAN;MASCARI MARK;GALVIN GABRIEL;STEIN GREGORY;MCCONLOGUE CARY;COMEZOGLU FAHRI |
| 分类号 |
C07D417/06;C12P17/02;A61K;C07D417/02;C07D493/00;C07D493/04;C12N1/20;C12N5/06;C12N9/52;C12P17/14;C12P17/16;C12P17/18 |
主分类号 |
C07D417/06 |
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