发明名称 |
Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof |
摘要 |
A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the Cripto-1 gene product is indicative of a neurodegenerative disease in the mammal; a method of inhibiting progression of a neurodegenerative disease in a mammal, which method comprises administering to the mammal an agent that inhibits Cripto-1 in an amount effective to inhibit Cripto-1 in the central nervous system of the mammal, whereupon the progression of the neurodegenerative disease is inhibited; and an isolated or purified oligonucleotide consisting essentially of the sequence of AAGCTATGGACTGCAGGAAGATGG (SEQ ID NO: 3) or AGAAGGCAGATGCCACTAGC (SEQ ID NO: 4).
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申请公布号 |
US2007122813(A1) |
申请公布日期 |
2007.05.31 |
申请号 |
US20040574645 |
申请日期 |
2004.10.01 |
申请人 |
SALOMON DAVID;BERMAN NANCY;STEPHENS EDWARD |
发明人 |
SALOMON DAVID;BERMAN NANCY;STEPHENS EDWARD |
分类号 |
C12Q1/68;A61K39/395;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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主权项 |
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地址 |
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