发明名称 |
STABILIZED POLYMERIC THIOL REAGENTS |
摘要 |
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y-S-W]<SUB>x</SUB>,, where POLY is a water soluble polymer; Y is a hydrocarbonbased spacer group, x is 1 to 25, and S-W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use. |
申请公布号 |
WO2006069388(A3) |
申请公布日期 |
2007.05.31 |
申请号 |
WO2005US47337 |
申请日期 |
2005.12.21 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION;KOZLOWSKI, ANTONI;MCMANUS, SAMUEL |
发明人 |
KOZLOWSKI, ANTONI;MCMANUS, SAMUEL |
分类号 |
A61K47/48;C07C323/12;C07D213/70 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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