COMPOSITIONS AND METHODS FOR AMELIORATING TOXINS AND VIRULENCE FACTORS

摘要

The invention provides methods of ameliorating or preventing toxicity associated with a virulence factor or toxin (e.g., a microbial virulence factor, e.g., from Clostridium) in a subject, comprising administering to the subject in need thereof, a therapeutically effective amount of polypeptide having a protease activity, e.g., an isolated, recombinant or synthetic protease or antibody having protease activity, wherein the polypeptide (e.g., protease) partially or completely neutralizes the virulence factor or a toxin, thereby ameliorating or preventing the toxicity associated with the virulence factor or toxin.