| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for making heart failure model animals by a simple and low-cost method. SOLUTION: This method for producing Zebrafish (for example, Danio rerio) exhibiting a heart failure symptom comprises breeding fertilized Zebrafish eggs in the presence of a chemical substance, such as tacrolimus hydrate or astemizole. The method for identifying a candidate of heart failure remedy comprises using the obtained Zebrafish exhibiting the heart failure symptom. The Zebrafish exhibiting a heart failure symptom is useful as a model animal for researches and developments related to the treatments and preventions of heart failures. COPYRIGHT: (C)2007,JPO&INPIT
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