发明名称 |
Mutant forms of cholera holotoxin as an adjuvant |
摘要 |
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
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申请公布号 |
US2007122428(A1) |
申请公布日期 |
2007.05.31 |
申请号 |
US20060644503 |
申请日期 |
2006.12.22 |
申请人 |
UNIVERSITY OF HEALTH SCIENCES |
发明人 |
GREEN BRUCE A.;HOLMES RANDALL K.;JOBLING MICHAEL G.;ZHU DUZHANG |
分类号 |
A61K39/295;C12N15/09;A61K39/00;A61K39/002;A61K39/008;A61K39/015;A61K39/02;A61K39/04;A61K39/05;A61K39/07;A61K39/08;A61K39/085;A61K39/09;A61K39/095;A61K39/10;A61K39/102;A61K39/106;A61K39/108;A61K39/112;A61K39/118;A61K39/12;A61K39/125;A61K39/13;A61K39/145;A61K39/15;A61K39/155;A61K39/165;A61K39/175;A61K39/20;A61K39/205;A61K39/21;A61K39/215;A61K39/23;A61K39/235;A61K39/245;A61K39/255;A61K39/265;A61K39/29;A61K39/35;A61K39/39;A61P35/00;C07H21/04;C07K14/185;C07K14/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/74;C12P21/02 |
主分类号 |
A61K39/295 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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