发明名称 |
METHODS FOR PROMOTING STEM CELL PROLIFERATION AND SURVIVAL |
摘要 |
It is disclosed herein that STAT3 phosphorylated at serine 727 is a key regulator of proliferation and survival of stem cells and precursor cells. Methods for increasing the survival and proliferation of stem cells and/or precursor are disclosed herein. In one embodiment, the method includes contacting a mammalian stem cell mammalian precursor cell with a JAK inhibitor, a p38 inhibitor, or both. Methods are also disclosed for increasing the survival and proliferation of neuronal precursor cells in a subject. The method includes administering a therapeutically effective amount of a Notch ligand and a growth factor. Methods are also disclosed for identifying an agent that increases the proliferation of stem cells and/or precursor cells. The method includes contacting a stem cell or a precursor cell with an agent of interest, wherein the stem cell or the precursor cell expresses STAT3; and determining the phosphorylation status of serine 727 of STAT3 in the cell. Phosphorylation of serine 727 indicates that the agent increases the survival and/or proliferation of stem cells and/or precursor cells. An isolated population of cells is disclosed, wherein the cells express nestin and STAT3, wherein serine 727 of STAT3 is phosphorylated. |
申请公布号 |
WO2007030693(A3) |
申请公布日期 |
2007.05.31 |
申请号 |
WO2006US34988 |
申请日期 |
2006.09.07 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES;MC KAY, RONALD, D., G.;ANDROUTSELLIS-THEOTOKIS, ANDREAS |
发明人 |
MC KAY, RONALD, D., G.;ANDROUTSELLIS-THEOTOKIS, ANDREAS |
分类号 |
C07K14/705;C12N5/0735;C12N5/074;C12N5/0797;C12N9/12 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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