QUINUCLIDINONE DERIVATIVES AS ANTICANCER AGENTS

摘要

New compounds of formula (I): wherein R<SUB>1</SUB> and R<SUB>2</SUB> may be the same or different and are selected from H, halo, alkyl, cycloalkyl, haloalkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, hydroxyl, acetate, ketal, alkoxy, and combinations thereof, and combinations thereof, or R<SUB>1</SUB> and R<SUB>2</SUB> may form a ring, as with an alkyl, alkenyl, substituted alkyl or substituted alkenyl bridge, and R<SUB>3</SUB> is O or hydroxyl. Also encompassed are derivatives, metabolites, and prodrugs thereof. Also provided are methods for preparing the quinuclidinone analogs disclosed herein. Further provided are methods of treating, preventing or delaying the onset of a cancer in a subject in need of such treatment by administering a an effective amount of a compound of formula (I), or a derivative, metabolite or prodrug thereof to a subject diagnosed with cancer or at risk of developing cancer.