摘要 |
A bicyclic cinnamide compound represented by the formula (I) [wherein (II) indicates a single bond or double bond; Ar1 represents phenyl or pyridinyl optionally substituted by one to three substituents; R1 and R2 each represents C1-6 alkyl, hydroxy, etc.; Z1 represents optionally substituted methylene or vinylene, oxygen, or imino optionally substituted by C1-6 alkyl or C1-6 acyl; and p, q, and r each is an integer of 0-2]. It functions to reduce the production of A.beta.40 and A.beta.42. It is hence useful especially as a preventive or remedy for neurodegenerative diseases of which A.beta. is causative, such as Alzheimer's disease and Down's syndrome.
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申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
YOSHIDA, YU;KITAZAWA, NORITAKA;TAKAISHI, MAMORU;SASAKI, TAKEO;KANEKO, TOSHIHIKO;ITO, KOICHI;MIYAGAWA, TAKEHIKO;DOI, ERIKO;KAWANO, KOKI;HAGIWARA, HIROAKI;KIMURA, TEIJI |