发明名称 |
ANTISENSE COMPOUNDS HAVING ENHANCED ANTI-MICRORNA ACTIVITY |
摘要 |
Antisense compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The antisense compounds exhibit enhanced anti- miRNA activity. Further provided are methods for enhancing the inhibitory activity of an antisense compound targeting a miRNA, comprising incorporating stability enhancing sugar modifications into the antisense compounds. |
申请公布号 |
WO2007027894(A3) |
申请公布日期 |
2007.05.31 |
申请号 |
WO2006US34032 |
申请日期 |
2006.08.29 |
申请人 |
ISIS PHARMACEUTICALS, INC.;ESAU, CHRISTINE;SWAYZE, ERIC, E. |
发明人 |
ESAU, CHRISTINE;SWAYZE, ERIC, E. |
分类号 |
A61K31/711;C07H19/06;C07H19/16;C12N15/11;C12N15/113 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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