BICYCLIC CINNAMIDE COMPOUND

摘要

A bicyclic cinnamide compound represented by the formula (I) [wherein (II) indicates a single bond or double bond; Ar₁ represents phenyl or pyridinyl optionally substituted by one to three substituents; R¹ and R² each represents C_1-6 alkyl, hydroxy, etc.; Z₁ represents optionally substituted methylene or vinylene, oxygen, or imino optionally substituted by C_1-6 alkyl or C_1-6 acyl; and p, q, and r each is an integer of 0-2]. It functions to reduce the production of Aß40 and Aß42. It is hence useful especially as a preventive or remedy for neurodegenerative diseases of which Aß is causative, such as Alzheimer's disease and Down's syndrome.