DIHYDROPYRIDINE DERIVATIVES USEFUL IN ANTITUMOR THERAPY

摘要

DIHYDROPYRIDINE DERIVATIVES OF FORMULA (I): A REPRESENTS A DIRECT LINKAGE AT THE PHENYL 4-POSITION; R IS HYDROGEN; ONE OF R3 AND R4 IS C1-C3 ALKYL UNSUBSTITUTED OR OMEGA SUBSTITUTED BY C1-C3 ALKOXY, AND THE OTHER,INDEPENDENTLY, IS: A) C1-C3 ALKYL SUBSTITUTED OR OMEGA SUBSTITUTED BY C1-C3 ALKOXY; OR BE THE SAME OR DIFFERENT IS AN INTEGER OF 1 TO 3, EACH OF RA AND RB, WHICH MAY BE THE SAME OR DIFFERENT, IS HYDROGEN OR C1-C3 ALKYL; R5 IS HYDROGEN OR C1-C6 ALKYL UNSUBSTITUTED OR SUBSTITUTED BY MORPHOLINO; AND EACH OF R1 AND R2 IS INDEPENDENTLY A GROUP - OR' WHEREIN R' IS C1-C6 ALKYL; AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF ARE USEFUL ANTITUMOR ACTIVITY PROMOTING AGENTS .