Nucleic acid constructs useful in the treatment of HPV infection

摘要

Disclosed is a polynucleotide sequence encoding a HPV polypeptide comprising an epitope from an E1 antigen of HPV 6b, an epitope from HPV 6b E2, and an epitope from HPV 11 E2 and wherein the polynucleotide has a codon usage coefficient for human genes of greater than 0.4 and less than 1.0. Also disclosed is pharmaceutical compositions comprising the polynucleotide sequences and the use of the polynucleotide in the manufacture of a medicament for the treatment or prophylaxis of HPV infection.