发明名称 |
LEFTY, LEFTY DERIVATIVES AND USES THEROF |
摘要 |
The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may be fused to other functional heterologous proteins such as IgG, especially the Fc portion of IgG. Accrording to the disclosure, Lefty polypeptides are useful in the treatment of a variety of disorders, including, for example, neuronal diseases, muscle and bone conditions, and metabolic disorders. |
申请公布号 |
WO2007006025(A3) |
申请公布日期 |
2007.05.31 |
申请号 |
WO2006US26443 |
申请日期 |
2006.06.30 |
申请人 |
ACCELERON PHARMA INC.;KNOPF, JOHN;SEEHRA, JASBIR;KUMAR, RAVINDRA |
发明人 |
KNOPF, JOHN;SEEHRA, JASBIR;KUMAR, RAVINDRA |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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