METHOD FOR PREVENTING AND TREATING MAST CELL MEDIATED DISEASES

摘要

A method for preventing or treating mammalian diseases mediated by amphiregulin released from mast cells by administering an anti-amphiregulin antibody to a mammal. The antibody binds to the amphiregulin and prevents it from interacting with and activating mammalian cells that are involved in the pathogenesis of diseases. By preventing this binding and activation, the antibody prevents or treats any diseases mediated by amphiregulin released from the mast cells. Preferably, the method is used to prevent or treat allergic diseases, asthma, or fibrosis by reducing the affect of amphiregulin on the cells involved in such diseases.