METHOD FOR AMIDATING POLYPEPTIDES WITH BASIC AMINOACID C- TERMINALS BY MEANS OF SPECIFIC ENDOPROTEASES
摘要
The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
申请公布号
WO2007036299(A3)
申请公布日期
2007.05.31
申请号
WO2006EP08903
申请日期
2006.09.13
申请人
SANOFI-AVENTIS DEUTSCHLAND GMBH;RISSOM, SEBASTIAN;HABERMANN, PAUL;SALAGNAD, CHRISTOPHE;ZOCHER, FRANK;LANDRIC-BURTAIN, LAURE