| 摘要 |
The present invention relates to a pharmaceutical composition comprising a bispecific single chain antibody construct, said bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (V<SUB>H</SUB>) and the corresponding variable light chain regions (V<SUB>L</SUB>) regions are arranged, from N-terminus to C-terminus, in the order, V<SUB>H</SUB>(CD19)-V<SUB>L</SUB>(CD19)-V<SUB>H</SUB>(CD3)-V<SUB>L</SUB>(CD3), V<SUB>H</SUB>(CD3)-V<SUB>L</SUB>-(CD3)-V<SUB>H</SUB>(CD19)-V<SUB>L</SUB>(CD19) or V<SUB>H</SUB>(CD3)-V<SUB>L</SUB>(CD3)-V<SUB>L</SUB>(CD19)-V<SUB>H</SUB>(CD19). Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CD19 antigen are disclosed.
|
