BIOCOMPATIBLE COMPOSITION FOR REPLACING/REGENERATING TISSUES

摘要

A biocompatible composition for replacing/ regenerating articular tissues, in particular tissues of the nucleus pulposus but also not articular tissues such as bony tissues, providing a hydrogel matrix comprising a first and a second natural polymer, cells adapted to regenerate the tissue of the disc core, a cross linking agent suitable to cross-link at least one of said natural polymers in situ, thus giving to the biocompatible composition an appropriate resistance, and molecules adapted to stimulate the growth and/or the differentiation of cells, wherein one of the two natural polymers is sodium alginate. In a particular exemple, the above described composition before the cross-linking step has a starting density such that it is injectable. In particular, the cross linking action on sodium alginate is caused by a cross linking agent contained in biodegradable polymeric particles, released in a controlled way from natural polymers, for example gelatin, or starting from synthetic polymers, for example polylactic acid or copolymers of acid lactic-glycolic acid.