PROCESSES FOR REDUCING CONTAMINATING MICHAEL ACCEPTOR LEVELS IN OXYCODONE AND OTHER COMPOSITIONS
摘要
The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.
申请公布号
CA2630703(A1)
申请公布日期
2007.05.31
申请号
CA20062630703
申请日期
2006.11.22
申请人
CONTROLLED CHEMICALS, INC.
发明人
WANG, HAO;TELYATNIKOV, VLADISLAV V.;SHAFER, JULES A.