发明名称 |
Conjugated macromolecules |
摘要 |
A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having free amine groups in an aqueous basic solution; (b) forming a second solution by combining at least one carboxylate-containing molecule with at least one acid acceptor in an aprotic solvent; (c) adding at least one carboxylate activating agent to the second solution to form an activated carboxylate-containing molecule; (d) combining the first solution and second solutions to form a multiphasic solution; and (e) isolating the resultant substituted macromolecule from the mixture. A substituted macromolecule produced by the aforementioned method is also provided. Further provided is a method of enhancing a magnetic resonance image of a subject including administering the carboxylate-containing molecule-substituted macromolecule produced by the aforementioned method.
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申请公布号 |
US2007122346(A1) |
申请公布日期 |
2007.05.31 |
申请号 |
US20050290684 |
申请日期 |
2005.11.30 |
申请人 |
UZGIRIS EGIDIJUS E;GRIMMOND BRIAN J |
发明人 |
UZGIRIS EGIDIJUS E.;GRIMMOND BRIAN J. |
分类号 |
C07F5/00;A61K49/10 |
主分类号 |
C07F5/00 |
代理机构 |
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地址 |
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