| 摘要 |
Disclosed are halogen substituted 4-phenyl-1-piperazinyl derivatives of formula (I), their enantiomers and acid addition salts, having high affinity for D4 receptors are disclosed, wherein: W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH; R1 and R2 are independently selected from hydrogen and halogen, provided at least one of R1 and R2 is a halogen atom; R3 is selected from hydrogen, halogen,C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, trifluoromethyl, C1-6-alkoxy, aryloxy, aralkoxy, hydroxy, amino, C1-6-alkylamino, di(C1-6- alkyl)amino, nitro and cyano; n is 2, 3, 4 or 5; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula (a), wherein the variables R4 to R8 are as defined in the specification. Also disclosed is the use of said compounds in the treatment of psychosis, affective disorders, depression, aggression, cognitive disorders or dyskinesia induced by treatment with L-dopa.
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