发明名称 |
Use of procyanidin B2 for the preparation of a medicament for the treatment of amyloid and synuclein diseases |
摘要 |
<p>Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin BZ in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.</p> |
申请公布号 |
EP1790648(A1) |
申请公布日期 |
2007.05.30 |
申请号 |
EP20070004077 |
申请日期 |
2003.10.10 |
申请人 |
PROTEOTECH, INC. |
发明人 |
CASTILLO, GERARDO M.;NGUYEN, BETH P.;CHOI, PAULA Y.;LARSEN, LESLEY;LORIMER, STEPHEN D.;SNOW, ALAN D. |
分类号 |
C07D407/04;A61K31/41;A61P25/16;A61P25/28;C07D311/62;C07D311/74 |
主分类号 |
C07D407/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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