| 发明名称 |
Nitrooxy derivatives of losartan, valsartan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases |
| 摘要 |
Angiotensin II receptor blocker nitroderivatives of formula (I): <?in-line-formulae description="In-line Formulae" end="lead"?>R-(Y-ONO<SUB>2</SUB>)<SUB>s</SUB> (I) <?in-line-formulae description="In-line Formulae" end="tail"?> having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular, renal and chronic liver diseases and inflammatory processes. |
| 申请公布号 |
ZA200600856(B) |
申请公布日期 |
2007.05.30 |
| 申请号 |
ZA20060000856 |
申请日期 |
2006.01.30 |
| 申请人 |
NICOX S.A. |
发明人 |
ALMIRANTE, NICOLETTA;ONGINI, ENNIO;DEL SOLDATA, PIERO |
| 分类号 |
A61K;C07D;C07D235/20;C07D257/04;C07D403/10;C07D409/06 |
主分类号 |
A61K |
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