发明名称 |
TIE COMPLEX BINDING PROTEINS |
摘要 |
<p>Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.</p> |
申请公布号 |
EP1789451(A2) |
申请公布日期 |
2007.05.30 |
申请号 |
EP20050784935 |
申请日期 |
2005.08.09 |
申请人 |
DYAX CORPORATION |
发明人 |
WOOD, CLIVE R.;DRANSFIELD, DANIEL T.;PIETERS, HENK;HOET, RENE;HUFTON, SIMON E. |
分类号 |
A61K39/395;A61P35/00;C07H21/04;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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