发明名称 |
Controlled-release pharmaceutical composition and method for producing the same |
摘要 |
It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax. |
申请公布号 |
ZA200607603(B) |
申请公布日期 |
2007.05.30 |
申请号 |
ZA20060007603 |
申请日期 |
2006.09.11 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
YOSHITAKE, TAKASHI;MOROSHIMA, KENJI;MIZUNO, MITSURU;AOKI, SHIGERU |
分类号 |
A61K;A61K9/14;A61K9/28;A61K9/36;A61K9/62;A61K31/4439;A61K47/06;A61K47/10;A61K47/12;A61K47/14;A61K47/32;A61K47/38;A61P;A61P1/04;C07D;C07D401/12 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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