Coating for medical devices comprising PI 3-kinase inhibitor

摘要

The implantable medical drug delivery system like stent, stent-graft or anastomotic device comprising a) an implantable structure; b) a combination of anti-restenotic agent and phosphoinositide (PI) 3-kinase inhibitor directly affixed to the medical device in a single multiple polymeric layer architecture; and c) an additional polymeric coating for controling the elution rate of the ant-restenotic agent and PI 3-kinase inhibitor. These therapeutic agents can reduce a biological organism's reaction to the introduction of the medical device to the organism.