| 摘要 |
An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an anti-HIV drug. There is provided a compound represented by the formula:
(wherein,
Y is NR 4 (R 4 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted aralkyl), O, S, SO, or SO 2 ;
R A is 1) a group represented by the formula: -COR 5 (wherein R 5 is a group selected from a substituent group A) , or 2) a group represented by the formula:
(wherein A C ring is an optionally substituted nitrogen-containing aromatic heterocycle in which, among atoms adjacent to an atom having a bond, at least one atom is an unsaturated nitrogen atom, and a broken line represents the presence or the absence of a bond);
R 1 is a hydrogen or lower alkyl;
X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene;
R 2 is a group selected from a substituent group A;
R 3 is hydrogen, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted amino, optionally substituted lower alkylamino, optionally substituted cycloalkyl, optionally substituted cycloalkyl lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclic group, or optionally substituted heterocyclic lower alkyl)
or a pharmaceutically acceptable salt thereof, or a solvate thereof.
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