发明名称 |
Polysaccharides derivatives with high antithromboitic activity in plasma |
摘要 |
The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent. |
申请公布号 |
ZA200601643(B) |
申请公布日期 |
2007.05.30 |
申请号 |
ZA20060001643 |
申请日期 |
2006.02.24 |
申请人 |
INALCO S.P.A. |
发明人 |
MANONI, MARCO;SALSINI, LIANA;CHINI, JACOPO;CIPOLLETTI, GIOVANNI |
分类号 |
A61K;A61K31/726;C08B;C08B37/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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