发明名称 |
METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES |
摘要 |
The present invention relates to an improved process for preparing chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine on an industrial scale using an asymmetric hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine. |
申请公布号 |
EP1789385(A1) |
申请公布日期 |
2007.05.30 |
申请号 |
EP20050707642 |
申请日期 |
2005.02.26 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
SCHIFFERS, ROBERT;KREYE, PAUL;BAUMGARTEN, WOLFGANG;COLLET, ROSEMARIE |
分类号 |
C07D201/00;C07D333/16;C07D333/20 |
主分类号 |
C07D201/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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