发明名称 |
FRACTIONATION OF CHARGED POLYSACCHARIDE |
摘要 |
Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatised therapeutic agents intended for use in humans and animals. |
申请公布号 |
EP1789454(A1) |
申请公布日期 |
2007.05.30 |
申请号 |
EP20050794240 |
申请日期 |
2005.08.12 |
申请人 |
LIPOXEN TECHNOLOGIES LIMITED |
发明人 |
JAIN, Sanjay;PAPAIOANNOU, Ioannis;LAING, Peter |
分类号 |
B01D15/36;B01D15/42;C07K1/18;C07K14/61;C08B37/00 |
主分类号 |
B01D15/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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