| 发明名称 |
Bi-cyclic pyrimidine inhibitors of TGFbeta |
| 摘要 |
Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFbeta activity.
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| 申请公布号 |
US7223766(B2) |
申请公布日期 |
2007.05.29 |
| 申请号 |
US20040811428 |
申请日期 |
2004.03.26 |
| 申请人 |
SCIOS, INC. |
发明人 |
DUGAR SUNDEEP;CHAKRAVARTY SARVAJIT;CONTE AURELIA;AXON JONATHAN;MCENROE GLENN;MURPHY ALISON |
| 分类号 |
A61K31/517;A61K31/519;C07D239/70;C07D239/94;C07D401/12;C07D487/02;C07D487/04;C07D491/02;C07D491/04;C07D495/04;C07D498/02;C07D498/04 |
主分类号 |
A61K31/517 |
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