| 发明名称 |
Targeted proteolysis by recruitment to ubiquitin protein ligases |
| 摘要 |
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.
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| 申请公布号 |
US7223556(B1) |
申请公布日期 |
2007.05.29 |
| 申请号 |
US19990415795 |
申请日期 |
1999.10.08 |
| 申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
ZHOU PENGBO;HOWLEY PETER M. |
| 分类号 |
C12P21/06;A61K47/48;C07H21/04;C07K14/025;C07K14/47;C12N5/16;C12N5/18;C12N5/22;C12N9/00;C12N15/62 |
主分类号 |
C12P21/06 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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