发明名称 |
Blocking leukocyte emigration and inflammation by interfering with CD99/HEC2 |
摘要 |
The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.
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申请公布号 |
US7223395(B2) |
申请公布日期 |
2007.05.29 |
申请号 |
US20030221758 |
申请日期 |
2003.03.27 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
MULLER WILLIAM A.;SCHENKEL ALAN R. |
分类号 |
A61K39/395;A61K48/00;C07K16/28;C12N15/85;G01N33/50 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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