PROCESS FOR REDUCING RNA CONCENTRATION IN A MIXTURE OF BIOLOGICAL MATERIAL USING DIATOMACEOUS EARTH

摘要

The invention relates to a process for reducing RNA concentration in a mixtu re of biological material, comprising the steps of: (a) providing a mixture of biological material having a first concentration of RNA; (b) filtering the mixture through a diatomaceous earth material to produce a filtrate having a second concentration of RNA, wherein the second concentration is less than the first concentration; and (c) collecting the filtrate having a reduced RNA concentration. In one aspec t, the diatomaceous earth material serves to purify recombinant plasmid DNA from an RNA component in a mixture of biological material, and i n another aspect, it serves to separate different forms of soluble RNA in a mixture of biological material.