DRUGS TO IMPROVE SYNAPTIC TRANSMISSION

摘要

Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal tissues. Novel Brefeldin A analogs of the following structures are provided: <IMG> wherein each R is independently selected from -OH, OR1, -SH, -SR1, -NR2R2, and a carbonyl oxygen; each R' is independently a C1 to C4 alkyl; each R* is independently hydrogen or -OH; and wherein R1 is a C1 to C4 alkyl; and R2 is hydrogen or a C1 to C4 alkyl.