STABLE FIXED-DOSE FORMULATIONS CONTAINING A COMBINATION OF ANTIVIRALS, METHOD FOR PRODUCING THEREOF USING DRY GRANULATION

摘要

This invention is directed to a composition comprising dry granulated tenofovir DF and emtricitabine, and a inethod for making same. Dry granulation was unexpectedly found to be important in preparing a tenofovir DF containing composition suitable for inclusion in a combination dosage form containing emtricitabine, efavirenz and tenofovir DF.