LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 CLEARS AMYLOID-BETA PEPTIDE A CROSS THE BLOOD-BRIAN BARRIER VIA APOLIPOPROTEIN J

摘要

Low-density lipoprotein receptor-related protein 2 (LRP2) is a potential receptor to regulate the level of apolipoprotein J (apoJ) in the central nervous system, which is the major carrier of amyloid-ß peptide (Aß). ApoJ is cleared from brain interstitial fluid (ISF) and cerebrospinal fluid (CSF) by LRP2-mediated transcytosis across epithelial and endothelial barriers. At physiological ISF/CSF levels, apoJ is rapidly transported by LRP2 across the blood-brain barrier (BBB). Importantly, apoJ also substantially enhances clearance from the brain of amyloidogenic Aß isoforms (i.e., higher ß-sheet content such as Aß42) as apoJ-Aß by LRP2-mediated transport.