| 摘要 |
<p>The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule that comprises a cytokine family receptor protein, such as IL-1 receptor alpha subunit (IL-1Ra), IL-3 receptor alpha subunit (IL-3Ra), IL-7 receptor alpha subunit (IL-7Ra), growth hormone receptor (GHR) or a ligand thereof, such as IL-1 receptor antagonist (Il-1RA) or chimeric molecules thereof comprising at least a portion of the protein molecule, such as IL-1Ra-Fc, IL-3Ra-Fc, IL-7Ra-Fc, GHR-Fc, IL-1RA-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.</p> |
| 申请人 |
APOLLO LIFE SCIENCES LIMITED;PRIEST, JOHN, D.;WATTS, ALAN, D.;THOMAS, NIKOLIEN, S.;LIDDELL, CATHERINE, A.;PILKINGTON, GLENN, R.;WHITTAKER, JASON, S.;DOMAGALA, TERESA, A.;SIMPSON, RAINA, J. |
发明人 |
PRIEST, JOHN, D.;WATTS, ALAN, D.;THOMAS, NIKOLIEN, S.;LIDDELL, CATHERINE, A.;PILKINGTON, GLENN, R.;WHITTAKER, JASON, S.;DOMAGALA, TERESA, A.;SIMPSON, RAINA, J. |
