发明名称 |
METHOD FOR EVALUATION OF COMPOUND CAPABLE OF ACTING ON PLK3 |
摘要 |
It is found that topoisomerase IIa is a substrate for PLK3 and the phospholylated site in topoisomerase IIa corresponds to Thr at position 1342. Based on the finding, the evaluation (e.g., screening) of a compound for use as a therapeutic agent targeted to PlK3 becomes possible by using topoisomerase IIa or a substrate having the phospholylated site therein as a substrate. It is also found that the morphological change of a cancer cell having activated Ras is observed when PLK3 is over-expressed or activated. Based on the finding, a method for evaluation of a PLK3 activator and the PLK3 activator are provided.
|
申请公布号 |
WO2007037133(A9) |
申请公布日期 |
2007.05.24 |
申请号 |
WO2006JP318308 |
申请日期 |
2006.09.07 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD.;IIDA, MASATO;KOMATANI, HIDEYA |
发明人 |
IIDA, MASATO;KOMATANI, HIDEYA |
分类号 |
C12Q1/48;A61K45/00;A61P25/00;A61P35/00;A61P43/00;C07K7/06;C07K7/08;C12N15/09;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
C12Q1/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|