ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN
摘要
<p>The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional group. Subsequent to binding an antigen, the reactive functional group is converted to a covalent bond by reaction with a group of complementary reactivity on the bound antigen. The invention also provides bispecific antibodies with infinite binding affinity that comprise a second domain that specifically binds a metal chelate. The invention further provides methods of using such antibodies to diagnose and treat diseases and conditions.</p>
申请公布号
WO2007058725(A2)
申请公布日期
2007.05.24
申请号
WO2006US40131
申请日期
2006.10.12
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MEARES, CLAUDE, F.;BUTLIN, NATHANIEL, G.;MCCOY, MARK, R.;CORNEILLIE, TODD, M.
发明人
MEARES, CLAUDE, F.;BUTLIN, NATHANIEL, G.;MCCOY, MARK, R.;CORNEILLIE, TODD, M.