An automatic two-wheeled vehicle comprises a body frame (1) and an engine (20) mounted on the body frame. The body frame includes right and left frame members (tank rails)(3, 3) disposed on the lateral one and the other sides, a cross member (50) connecting the right and left frame members to each other, and a bracket (53) formed integrally with the cross member. The cylinder part (cylinder head)(24) of the engine is directly connected to the bracket.