发明名称 |
HUMAN SYNTHETIC SINGLE-CHAIN ANTIBODIES DIRECTED AGAINST THE COMMON EPITOPE OF MUTANT P53 AND THEIR USES |
摘要 |
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention. |
申请公布号 |
WO2006100681(A3) |
申请公布日期 |
2007.05.24 |
申请号 |
WO2006IL00372 |
申请日期 |
2006.03.23 |
申请人 |
RAMOT AT TEL AVIV UNIVERSITY LTD.;SOLOMON, BEKA;ORGAD, SARA;BENHAR, ITAI;ROSENFELD, RONIT |
发明人 |
SOLOMON, BEKA;ORGAD, SARA;BENHAR, ITAI;ROSENFELD, RONIT |
分类号 |
C07K16/18;A61K39/00;C07K16/32;C12N15/13 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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