发明名称 |
Processes for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine and hydrochloride thereof |
摘要 |
Processes for preparing 1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-yl]methylpiperidine (donepezil), which is useful as an intermediate for medicines, and for producing 1-benzyl-4-[(5,6-dimethoxy- 1 -indanon)-2-yl]methylpiperidine hydrochloride (donepezil hydrochloride), which is useful as a medicine. The process for donepezil hydrochloride production comprises catalytically hydrogenating the compound represented by the structural formula (III) [1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-ylidene]methylpiperidine] with a Raney nickel catalyst under mild conditions and subsequently treating it with hydrochloric acid. Thus, impurities are further diminished. The operations are simple and the process is suitable for industrial production.
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申请公布号 |
US2007117846(A1) |
申请公布日期 |
2007.05.24 |
申请号 |
US20050580908 |
申请日期 |
2005.04.27 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
IMAI AKIO;NISHIMURA HIROSHI |
分类号 |
C07D211/06;A61K31/445;B01J25/02;C07D211/32 |
主分类号 |
C07D211/06 |
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代理人 |
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主权项 |
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地址 |
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