LLO-ENCODING DNA/NUCLEIC ACID VACCINES AND METHODS COMPRISING SAME

摘要

The present invention provides vaccines, compositions, and recombinant vectors comprising a gene or mRNA encoding an N-terminal fragment of an LLO protein and an antigen, either fused together or encoded separately, and provides methods of invoking CD4⁺ and/or CD8⁺ T cell-mediated immune responses against an antigen and impeding the growth of or shrinking tumors, comprising same.