发明名称 |
PROCESS FOR THE PREPARATION OF DELMOPINOL AND DERIVATIVES THEREOF |
摘要 |
<p>A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including an hydrate, comprises reacting oxazolidin [2, 3-c] morpholine and a grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2, 3-c] morpholine and the grignard reagent are useful as intermediates in the production process.</p> |
申请公布号 |
WO2007057681(A1) |
申请公布日期 |
2007.05.24 |
申请号 |
WO2006GB04293 |
申请日期 |
2006.11.17 |
申请人 |
SINCLAIR PHARMACEUTICALS LIMITED;ARTUS SURROCA, JUAN JOSE;FERNANDEZ BLEDA, DAVID;IACOANGELI, TOMMASO;LLUIS TOUS, JORDI |
发明人 |
ARTUS SURROCA, JUAN JOSE;FERNANDEZ BLEDA, DAVID;IACOANGELI, TOMMASO;LLUIS TOUS, JORDI |
分类号 |
C07D265/30;C07D295/08;C07D295/088;C07D498/04;C07F3/02 |
主分类号 |
C07D265/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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