发明名称 |
Mutants of streptococcal toxin A and methods of use |
摘要 |
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin. |
申请公布号 |
EP1538208(A3) |
申请公布日期 |
2007.05.23 |
申请号 |
EP20050075021 |
申请日期 |
1996.06.07 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
SCHLIEVERT, PATRICK M.;ROGGIANI, MANUELA;STOEHR, JENNIFER;OHLENDORF, DOUGLAS |
分类号 |
C12N15/09;C12N15/31;A61K31/00;A61K38/00;A61K39/00;A61K39/09;A61P31/00;A61P31/04;C07K14/315;C12N1/21;C12N15/74 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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