Preparation of stereochemically pure oximes with muscarinic activity

摘要

The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo[2.2.1]heptan-3-one and 1-azabicyclo[2.2.2]heptan-3-one oximes to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.